Voiceprints Detect Early Alzheimer's; Leucovorin Guidance Issued; CTE and DNA Damage
Neurology > General Neurology
— News and commentary from the world of neurology and neuroscience
November 4, 2025 • 1 min read
Voiceprints Uncover Early Alzheimer's
Digital voice recordings have proven to be a powerful tool in the early detection of Alzheimer's and related dementias, according to a recent study published in npj Dementia. The research, a proof-of-concept, demonstrates the potential of voice analysis to identify subtle changes in speech patterns that may indicate the onset of these conditions.
Vamorolone Shows Promise in Duchenne Muscular Dystrophy
Santhera Pharmaceuticals has announced positive five-year data for vamorolone (Agamree), a treatment for Duchenne muscular dystrophy. The study revealed that vamorolone exhibited an improved safety profile and comparable effectiveness to corticosteroids, a standard treatment, offering new hope for patients.
Leucovorin Use in Autism: A Cautionary Note
The American Academy of Pediatrics has issued a statement advising against the routine use of leucovorin (folinic acid) for autistic children at this time. This decision highlights the ongoing research and need for careful consideration in the treatment of autism spectrum disorders.
Central Nervous System Cancers: Stabilizing Trends
A study published in JAMA Neurology reveals that the incidence rate of central nervous system cancers in the U.S. remained relatively stable from 1990 to 2021. However, disability-adjusted life-years and mortality rates showed a positive decline, indicating improvements in patient outcomes.
Gamification Boosts Parkinson's Patients' Steps
A small clinical trial published in JAMA Neurology demonstrated that a gamification intervention significantly increased daily steps among military veterans with Parkinson's disease, suggesting the potential of game-based approaches in managing symptoms.
BrainSTEM Atlas: Mapping the Developing Brain
The open-source BrainSTEM atlas, introduced in Science Advances, has mapped every cell of the developing human brain. This comprehensive resource may revolutionize Parkinson's research by providing detailed insights into brain development and function.
Retinal Impairment in Idiopathic Intracranial Hypertension
A prospective cohort study in Neurology identified two distinct mechanisms of structural and functional retinal impairment in patients with idiopathic intracranial hypertension, leading to vision problems. This finding contributes to a deeper understanding of the condition's impact on the visual system.
CTE and DNA Damage: A Genetic Link
Brain samples have revealed a connection between chronic traumatic encephalopathy (CTE) and DNA damage, similar to that observed in Alzheimer's disease. This discovery suggests that the same genetic changes may contribute to the neurodegeneration associated with CTE.
AMT-130: FDA Feedback and Huntington's Disease
uniQure has received feedback from the FDA regarding the phase I/II data of investigational AMT-130 in Huntington's disease. The feedback indicates that the current data may not be sufficient to proceed with a biologics license application, prompting further considerations in the development of treatments for this condition.
Cortical Glutamatergic and GABAergic Inputs: Memory Stabilization
A mouse study published in Science suggests that cortical glutamatergic and GABAergic inputs play a crucial role in stabilizing memory formation. This research contributes to our understanding of the neural mechanisms underlying memory consolidation.
